Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model

Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model

Antibiotic-tolerant bacterial biofilms are notorious in causing PJI. Antibiotic loaded calcium sulfate bead (CSB) bone void fillers and PMMA cement and powdered vancomycin (VP) have been used to achieve high local antibiotic concentrations; however, the effect of drainage on concentration is poorly...

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Bibliographic Details
Main Authors: Kelly Moore, Rebecca Wilson-van Os, Devendra H. Dusane, Jacob R. Brooks, Craig Delury, Sean S. Aiken, Phillip A. Laycock, Anne C. Sullivan, Jeffrey F. Granger, Matthew V. Dipane, Edward J. McPherson, Paul Stoodley
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antibiotics
Subjects:
periprosthetic joint infection
antibiotic loaded calcium sulfate beads
polymethylmethacrylate (PMMA) bone cement
vancomycin
tobramycin
Online Access:https://www.mdpi.com/2079-6382/10/3/270

Internet

https://www.mdpi.com/2079-6382/10/3/270

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