Hypoxia and hypoxia-inducible factors in leukaemias

Despite huge improvements in the treatment of leukaemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukaemic stem cells (LSCs) within the bone marrow, which are able to self-renew and therefore re-establish the full tumo...

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Bibliographic Details
Main Authors: Margaux eDeynoux, Nicola eSunter, Olivier eHérault, Frédéric eMazurier
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00041/full