Thermosensitive Gels Used to Improve Microneedle-Assisted Transdermal Delivery of Naltrexone

Transdermal delivery of naltrexone (NTX) can be enhanced using microneedles, although micropores generated this way can reseal by 48 h in humans, which prevents further drug delivery from a formulation. Poloxamer 407 (P407) is a thermosensitive polymer that may extend microneedle-assisted NTX delive...

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Bibliographic Details
Main Authors: Kevin V. Tobin, Jennifer Fiegel, Nicole K. Brogden
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Polymers
Subjects:
Online Access:https://www.mdpi.com/2073-4360/13/6/933