A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival

A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival

Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensit...

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Main Authors: Ting Zhou, Tae Wan Kim, Chi Nok Chong, Lei Tan, Sadaf Amin, Zohreh Sadat Badieyan, Suranjit Mukherjee, Zaniar Ghazizadeh, Hui Zeng, Min Guo, Miguel Crespo, Tuo Zhang, Reyn Kenyon, Christopher L. Robinson, Effie Apostolou, Hui Wang, Jenny Zhaoying Xiang, Todd Evans, Lorenz Studer, Shuibing Chen
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07201-1
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spelling doaj-73d56573bdd642718c8b15d27f8152fb2021-05-11T09:28:06ZengNature Publishing GroupNature Communications2041-17232018-11-019111310.1038/s41467-018-07201-1A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survivalTing Zhou0Tae Wan Kim1Chi Nok Chong2Lei Tan3Sadaf Amin4Zohreh Sadat Badieyan5Suranjit Mukherjee6Zaniar Ghazizadeh7Hui Zeng8Min Guo9Miguel Crespo10Tuo Zhang11Reyn Kenyon12Christopher L. Robinson13Effie Apostolou14Hui Wang15Jenny Zhaoying Xiang16Todd Evans17Lorenz Studer18Shuibing Chen19Department of Surgery, Weill Cornell Medical CollegeThe Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer ResearchDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeGenomic Resource Core Facility, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeDepartment of Medicine, Weill Cornell Medical CollegeSchool of Public health, Shanghai Jiao Tong University, School of MedicineGenomic Resource Core Facility, Weill Cornell Medical CollegeDepartment of Surgery, Weill Cornell Medical CollegeThe Center for Stem Cell Biology, Sloan-Kettering Institute for Cancer ResearchDepartment of Surgery, Weill Cornell Medical CollegeDiseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.https://doi.org/10.1038/s41467-018-07201-1
collection DOAJ
language English
format Article
sources DOAJ
author Ting Zhou
Tae Wan Kim
Chi Nok Chong
Lei Tan
Sadaf Amin
Zohreh Sadat Badieyan
Suranjit Mukherjee
Zaniar Ghazizadeh
Hui Zeng
Min Guo
Miguel Crespo
Tuo Zhang
Reyn Kenyon
Christopher L. Robinson
Effie Apostolou
Hui Wang
Jenny Zhaoying Xiang
Todd Evans
Lorenz Studer
Shuibing Chen
spellingShingle Ting Zhou
Tae Wan Kim
Chi Nok Chong
Lei Tan
Sadaf Amin
Zohreh Sadat Badieyan
Suranjit Mukherjee
Zaniar Ghazizadeh
Hui Zeng
Min Guo
Miguel Crespo
Tuo Zhang
Reyn Kenyon
Christopher L. Robinson
Effie Apostolou
Hui Wang
Jenny Zhaoying Xiang
Todd Evans
Lorenz Studer
Shuibing Chen
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
Nature Communications
author_facet Ting Zhou
Tae Wan Kim
Chi Nok Chong
Lei Tan
Sadaf Amin
Zohreh Sadat Badieyan
Suranjit Mukherjee
Zaniar Ghazizadeh
Hui Zeng
Min Guo
Miguel Crespo
Tuo Zhang
Reyn Kenyon
Christopher L. Robinson
Effie Apostolou
Hui Wang
Jenny Zhaoying Xiang
Todd Evans
Lorenz Studer
Shuibing Chen
author_sort Ting Zhou
title A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
title_short A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
title_full A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
title_fullStr A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
title_full_unstemmed A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
title_sort hpsc-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.
url https://doi.org/10.1038/s41467-018-07201-1
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