Modeling Notch-Induced Tumor Cell Survival in the <i>Drosophila</i> Ovary Identifies Cellular and Transcriptional Response to Nuclear NICD Accumulation

Modeling Notch-Induced Tumor Cell Survival in the <i>Drosophila</i> Ovary Identifies Cellular and Transcriptional Response to Nuclear NICD Accumulation

Notch is a conserved developmental signaling pathway that is dysregulated in many cancer types, most often through constitutive activation. Tumor cells with nuclear accumulation of the active Notch receptor, NICD, generally exhibit enhanced survival while patients experience poorer outcomes. To unde...

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Bibliographic Details
Main Authors: Allison Jevitt, Yi-Chun Huang, Su-Mei Zhang, Deeptiman Chatterjee, Xian-Feng Wang, Geng-Qiang Xie, Wu-Min Deng
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
<i>Drosophila</i>
Notch
NICD
follicle
epithelium
nuclear
Online Access:https://www.mdpi.com/2073-4409/10/9/2222

Internet

https://www.mdpi.com/2073-4409/10/9/2222

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