Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.

Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.

The purpose of our study was to understand if Toll-like receptor 9 (TLR9) activation could contribute to the control of inflammation in Sjogren's syndrome. To this end, we manipulated TLR9 signaling in non-obese diabetic (NOD) and TLR9(-/-) mice using agonistic CpG oligonucleotide aptamers, TLR...

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Bibliographic Details
Main Authors: Adi Gilboa-Geffen, Yochai Wolf, Geula Hanin, Naomi Melamed-Book, Marjorie Pick, Estelle R Bennett, David S Greenberg, Susan Lester, Maureen Rischmueller, Hermona Soreq
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174879/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22174879/?tool=EBI

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