Characterization of Weak Protein Domain Structure by Spin-Label Distance Distributions

Characterization of Weak Protein Domain Structure by Spin-Label Distance Distributions

Function of intrinsically disordered proteins may depend on deviation of their conformational ensemble from that of a random coil. Such deviation may be hard to characterize and quantify, if it is weak. We explored the potential of distance distributions between spin labels, as they can be measured...

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Bibliographic Details
Main Authors: Irina Ritsch, Laura Esteban-Hofer, Elisabeth Lehmann, Leonidas Emmanouilidis, Maxim Yulikov, Frédéric H.-T. Allain, Gunnar Jeschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
low-complexity domains
RNA-binding proteins
ensemble structure
EPR spectroscopy
random coil
intrinsically disordered
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.636599/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.636599/full

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