Human Cord Blood Derived Unrestricted Somatic Stem Cells Restore Aquaporin Channel Expression, Reduce Inflammation and Inhibit the Development of Hydrocephalus After Experimentally Induced Perinatal Intraventricular Hemorrhage

Human Cord Blood Derived Unrestricted Somatic Stem Cells Restore Aquaporin Channel Expression, Reduce Inflammation and Inhibit the Development of Hydrocephalus After Experimentally Induced Perinatal Intraventricular Hemorrhage

Intraventricular hemorrhage (IVH) is a severe complication of preterm birth associated with cerebral palsy, intellectual disability, and commonly, accumulation of cerebrospinal fluid (CSF). Histologically, IVH leads to subependymal gliosis, fibrosis, and disruption of the ependymal wall. Importantly...

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Bibliographic Details
Main Authors: Deepti Purohit, Dina A. Finkel, Ana Malfa, Yanling Liao, Larisa Ivanova, George M. Kleinman, Furong Hu, Shetal Shah, Carl Thompson, Etlinger Joseph, Michael S. Wolin, Mitchell S. Cairo, Edmund F. La Gamma, Govindaiah Vinukonda
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
unrestricted somatic stem cells
intraventricular hemorrhage
hydrocephalus
aquaporin (AQP)
choroid plexus
ependymal wall
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.633185/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.633185/full

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