Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats

Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats

The clinical usage of doxorubicin (DOX), a potent anthracycline antineoplastic drug, is often limited by its cardiotoxic effects. Thus, for improving usage of DOX, the aim of this study was to assess the cardioprotective effects of nerolidol (NERO) in a rat model of DOX-induced acute cardiotoxicity...

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Bibliographic Details
Main Authors: Seenipandi Arunachalam, M. F. Nagoor Meeran, Sheikh Azimullah, Charu Sharma, Sameer N. Goyal, Shreesh Ojha
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
acute cardiotoxicity
cardioprotective
doxorubicin
inflammation
nerolidol
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/10/6/984

Internet

https://www.mdpi.com/2076-3921/10/6/984

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