Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure
<p>Abstract</p> <p>The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of <it>Esc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-09-01
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| Series: | Theoretical Biology and Medical Modelling |
| Online Access: | http://www.tbiomed.com/content/6/1/20 |