Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E. coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model

Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E. coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model

Rapidly changing concentrations of substrates frequently occur during large-scale microbial cultivations. These changing conditions, caused by large mixing times, result in a heterogeneous population distribution. Here, we present a powerful and efficient modeling approach to predict the influence o...

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Bibliographic Details
Main Authors: Alexander Nieß, Michael Löffler, Joana D. Simen, Ralf Takors
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Microbiology
Subjects:
scale-down
hybrid modeling
population heterogeneity
adaptation times
Escherichia coli
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01195/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01195/full

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