Long non-coding RNA CASC2 suppresses pulmonary artery smooth muscle cell proliferation and phenotypic switch in hypoxia-induced pulmonary hypertension

Long non-coding RNA CASC2 suppresses pulmonary artery smooth muscle cell proliferation and phenotypic switch in hypoxia-induced pulmonary hypertension

Abstract Background In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling. Methods The expression of lncRNAs or mRNAs was detected by qRT-PCR, and western blot analysis or immunochemistry was employ...

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Bibliographic Details
Main Authors: Junsong Gong, Zujun Chen, Yu Chen, Huanran Lv, Haisong Lu, Fuxia Yan, Lihuan Li, Weili Zhang, Jia Shi
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Respiratory Research
Subjects:
Pulmonary hypertension
Pulmonary artery smooth muscle cells (PASMCs)
lncRNA CASC2
Vascular remodeling; phenotypic switch
Online Access:http://link.springer.com/article/10.1186/s12931-019-1018-x

Internet

http://link.springer.com/article/10.1186/s12931-019-1018-x

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