Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio‐informatics study

Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio‐informatics study

Abstract Aldehyde Oxidase (hAOX1) is a cytosolic enzyme involved in the metabolism of drugs and xenobiotic compounds. The enzyme belongs to the xanthine oxidase (XO) family of Mo containing enzyme and is a homo‐dimer of two 150 kDa monomers. Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) of...

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Bibliographic Details
Main Authors: Catarina Coelho, Jayaraman Muthukumaran, Teresa Santos‐Silva, Maria João Romão
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Pharmacology Research & Perspectives
Subjects:
aldehyde oxidase
computational genomic
in silico analysis
pharmacogenetic
single nucleotide polymorphism
Online Access:https://doi.org/10.1002/prp2.538

Internet

https://doi.org/10.1002/prp2.538

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