Enhanced gastric retention and drug release via development of novel floating microspheres based on Eudragit E100 and polycaprolactone: synthesis and in vitro evaluation

Enhanced gastric retention and drug release via development of novel floating microspheres based on Eudragit E100 and polycaprolactone: synthesis and in vitro evaluation

Eudragit E 100 and polycaprolactone (PCL) floating microspheres for enhanced gastric retention and drug release were successfully prepared by oil in water solvent evaporation method. Metronidazole benzoate, an anti-protozoal drug, was used as a model drug. Polyvinyl alcohol was used as an emulsifier...

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Bibliographic Details
Main Authors: Umar Farooq, Samiullah Khan, Shahid Nawaz, Nazar Mohammad Ranjha, Malik Salman Haider, Muhammad Muzamil Khan, Eshwa Dar, Ahmad Nawaz
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Designed Monomers and Polymers
Subjects:
Floating microspheres
metronidazole benzoate
oil in water (o/w) method
gastric retention and drug release
Eudragit E 100
Online Access:http://dx.doi.org/10.1080/15685551.2017.1326702

Internet

http://dx.doi.org/10.1080/15685551.2017.1326702

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