Position effects influencing intrachromosomal repair of a double-strand break in budding yeast.

Repair of a double-strand break (DSB) by an ectopic homologous donor sequence is subject to the three-dimensional arrangement of chromosomes in the nucleus of haploid budding yeast. The data for interchromosomal recombination suggest that searching for homology is accomplished by a random collision...

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Bibliographic Details
Main Authors: Ruoxi W Wang, Cheng-Sheng Lee, James E Haber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5507452?pdf=render