Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function

Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function

Mitochondrial dysfunction plays an important role in mediating ischemic brain damage. Immp2l is an inner mitochondrial membrane peptidase that processes mitochondrial protein cytochrome c1 (Cyc1). Homozygous mutation of Immp2l (Immp2lTg(Tyr)979Ove or Immp2l−/−) elevates mitochondrial membrane potent...

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Bibliographic Details
Main Authors: Yi Ma, Suresh L. Mehta, Baisong Lu, P. Andy Li
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Neurobiology of Disease
Subjects:
Cerebral ischemia
Cell death mechanisms
Focal ischemia
Gene regulation
Immp2l
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002269

Internet

http://www.sciencedirect.com/science/article/pii/S0969996111002269

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