TP53 p.Arg337His germline mutation prevalence in Southern Brazil: Further evidence for mutation testing in young breast cancer patients.

TP53 p.Arg337His germline mutation prevalence in Southern Brazil: Further evidence for mutation testing in young breast cancer patients.

Premenopausal breast cancer (BC) is a core tumor of Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) Syndromes, predisposition disorders caused by germline mutations in TP53 gene. In the Southern and Southeastern regions of Brazil, a specific TP53 germline mutation, c.1010G>A (p.Arg337His), was ident...

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Bibliographic Details
Main Authors: Eriza Cristina Hahn, Camila Matzenbacher Bittar, Fernanda Sales Luis Vianna, Cristina Brinckmann Oliveira Netto, Jorge Villanova Biazús, Rodrigo Cericatto, José Antônio Cavalheiro, Márcia Portela de Melo, Carlos Henrique Menke, Eliane Rabin, Sandra Leistner-Segal, Patricia Ashton-Prolla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209934

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https://doi.org/10.1371/journal.pone.0209934

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