Verbascoside Protects Mice From Clostridial Gas Gangrene by Inhibiting the Activity of Alpha Toxin and Perfringolysin O

Verbascoside Protects Mice From Clostridial Gas Gangrene by Inhibiting the Activity of Alpha Toxin and Perfringolysin O

Gas gangrene, caused mainly by the anaerobic bacterium Clostridium perfringens (C. perfringens), causes death within 48 h of onset. Limited therapeutic strategies are available, and it is associated with extremely high mortality. Both C. perfringens alpha toxin (CPA) and perfringolysin O (PFO) are i...

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Bibliographic Details
Main Authors: Jian Zhang, Shui Liu, Lining Xia, Zhongmei Wen, Naiyu Hu, Tingting Wang, Xuming Deng, Jiakang He, Jianfeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Microbiology
Subjects:
alpha toxin
anti-infection
Clostridium perfringens
gas gangrene
perfringolysin O
verbascoside
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01504/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01504/full

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