Curcumin-Induced Heme Oxygenase-1 Expression Prevents H2O2-Induced Cell Death in Wild Type and Heme Oxygenase-2 Knockout Adipose-Derived Mesenchymal Stem Cells

Curcumin-Induced Heme Oxygenase-1 Expression Prevents H2O2-Induced Cell Death in Wild Type and Heme Oxygenase-2 Knockout Adipose-Derived Mesenchymal Stem Cells

Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered by oxidative stress at the site of injury. Heme oxygenase (HO) generates the cytoprotective effector molecules biliverdin/bilirubin, carbon...

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Bibliographic Details
Main Authors: Niels A. J. Cremers, Ditte M. S. Lundvig, Stephanie C. M. van Dalen, Rik F. Schelbergen, Peter L. E. M. van Lent, Walter A. Szarek, Raymond F. Regan, Carine E. Carels, Frank A. D. T. G. Wagener
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:International Journal of Molecular Sciences
Subjects:
adipose-derived mesenchymal stem cells
oxidative stress
apoptosis
heme oxygenase
carbon monoxide
Online Access:http://www.mdpi.com/1422-0067/15/10/17974

Internet

http://www.mdpi.com/1422-0067/15/10/17974

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