Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

In accordance with the prominent role of orexins in the maintenance of wakefulness via activation of orexin-1 (OX1R) and orexin-2 (OX2R) receptors, various dual OX1/2R antagonists have been shown to promote sleep in animals and humans. While selective blockade of OX2R seems to be sufficient to initi...

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Bibliographic Details
Main Authors: Christine eDugovic, Jonathan E Shelton, Sujin eYun, Pascal eBonaventure, Brock T Shireman, Timothy W Lovenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Neuroscience
Subjects:
rat
REM sleep
receptor antagonist
orexin-1
orexin-2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00028/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00028/full

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