Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation.

BACKGROUND:Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different acidic or neutral sphingomyelinases. This study w...

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Bibliographic Details
Main Authors: Raphael Devillard, Sylvain Galvani, Jean-Claude Thiers, Jean-Louis Guenet, Yusuf Hannun, Jacek Bielawski, Anne Nègre-Salvayre, Robert Salvayre, Nathalie Augé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2843740?pdf=render