Topologically heterogeneous beta cell adaptation in response to high-fat diet in mice.

Topologically heterogeneous beta cell adaptation in response to high-fat diet in mice.

AIMS:Beta cells adapt to an increased insulin demand by enhancing insulin secretion via increased beta cell function and/or increased beta cell number. While morphological and functional heterogeneity between individual islets exists, it is unknown whether regional differences in beta cell adaptatio...

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Bibliographic Details
Main Authors: Johanne H Ellenbroek, Hendrica A Töns, Natascha de Graaf, Cindy J Loomans, Marten A Engelse, Hans Vrolijk, Peter J Voshol, Ton J Rabelink, Françoise Carlotti, Eelco J de Koning
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3575501?pdf=render

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http://europepmc.org/articles/PMC3575501?pdf=render

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