Optimality conditions for cell-fate heterogeneity that maximize the effects of growth factors in PC12 cells.

Recently, the heterogeneity that arises from stochastic fate decisions has been reported for several types of cancer-derived cell lines and several types of clonal cells grown under constant environmental conditions. However, the relation between this stochasticity and the responsiveness to extracel...

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Bibliographic Details
Main Authors: Kazunari Mouri, Yasushi Sako
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3828137?pdf=render