Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model

Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model

The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by...

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Bibliographic Details
Main Authors: Nina Šaban, Višnja Stepanić, Srđan Vučinić, Anita Horvatić, Mario Cindrić, Ivana Perković, Branka Zorc, Nada Oršolić, Mladen Mintas, Krešimir Pavelić, Sandra Kraljević Pavelić
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer
amino acid hydroxyurea derivatives
HDAC inhibition
anti-proliferative effect
Online Access:http://www.mdpi.com/1422-0067/14/12/23654

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http://www.mdpi.com/1422-0067/14/12/23654

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