Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway

Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway

BackgroundThe NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been identified as an important mediator of blood–brain-barrier disruption in sepsis-associated encephalopathy (SAE). However, no information is available concerning the critical upstream regulators of SAE.Method...

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Bibliographic Details
Main Authors: Shenglong Chen, Chaogang Tang, Hongguang Ding, Zhonghua Wang, Xinqiang Liu, Yunfei Chai, Wenqiang Jiang, Yongli Han, Hongke Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
sepsis-associated encephalopathy
Maf1
blood–brain barrier disruption
NF-κB
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.594071/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.594071/full

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