Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells

Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells

Abstract Tobacco smoking is the largest risk factor for developing chronic obstructive pulmonary disease (COPD), and is associated with hyperresponsiveness of airway smooth muscle (ASM). Chronic exposure to cigarette smoke (CS) leads to airway inflammation and remodelling. However, the direct effect...

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Bibliographic Details
Main Authors: JinHeng Lin, Michael Taggart, Lee Borthwick, Andrew Fisher, Malcolm Brodlie, M. Flori Sassano, Robert Tarran, Michael A. Gray
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89051-4

Internet

https://doi.org/10.1038/s41598-021-89051-4

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