Triptriolide antagonizes triptolide-induced nephrocyte apoptosis via inhibiting oxidative stress in vitro and in vivo

Triptriolide antagonizes triptolide-induced nephrocyte apoptosis via inhibiting oxidative stress in vitro and in vivo

Triptolide(T9) is a predominant bioactive component extracted from Chinese herb Tripterygium wilfordii Hook F. (TwHF), and has multiple pharmacological activities, such as immunosuppressive and anti-inflammatory activities, et al. However, severe adverse effects and toxicity, particularly nephrotoxi...

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Bibliographic Details
Main Authors: Xiao-wan Wang, Rui-min Tian, Yi-qi Yang, Zhao-Yu Lu, Xiao-dong Han, Xu-sheng Liu, Wei Mao, Peng Xu, Hong-tao Xu, Bo Liu
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Triptriolide
Triptolide
Oxidative stress
Apoptosis
Nrf2 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219329191

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http://www.sciencedirect.com/science/article/pii/S0753332219329191

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