Applications of Mass Spectrometry in the Onset of Amyloid Fibril Formation: Focus on the Analysis of Early-Stage Oligomers

Applications of Mass Spectrometry in the Onset of Amyloid Fibril Formation: Focus on the Analysis of Early-Stage Oligomers

Amyloid fibril formation is a hallmark of diverse neurodegenerative and metabolic diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and type 2 diabetes mellitus (T2DM). Conventional diagnosis is based on the appearance of fibrils or plaques, while neglects the role of e...

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Bibliographic Details
Main Authors: Jiaojiao Hu, Qiuling Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Chemistry
Subjects:
mass spectrometry
amyloid fibril
aggregation mechanism
early-stage oligomers
conformational analysis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00324/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00324/full

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