Neuroanatomical and Microglial Alterations in the Striatum of Levodopa-Treated, Dyskinetic Hemi-Parkinsonian Rats

Neuroanatomical and Microglial Alterations in the Striatum of Levodopa-Treated, Dyskinetic Hemi-Parkinsonian Rats

Dyskinesia associated with chronic levodopa treatment in Parkinson’s disease is associated with maladaptive striatal plasticity. The objective of this study was to examine whether macroscale structural changes, as captured by magnetic resonance imaging (MRI) accompany this plasticity and to identify...

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Bibliographic Details
Main Authors: Edward J. R. Fletcher, Clare J. Finlay, Ana Amor Lopez, William R. Crum, Anthony C. Vernon, Susan Duty
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neuroscience
Subjects:
abnormal involuntary movements
astrocytes
6-Hydroxydopamine
levodopa-Induced dyskinesia
magnetic resonance imaging
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.567222/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.567222/full

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