<b>Bicyclic Basic Merbarone Analogues as Antiproliferative Agents</b>

<b>Bicyclic Basic Merbarone Analogues as Antiproliferative Agents</b>

Pyrimido-pyrimidine derivatives have been developed as rigid merbarone analogues. In a previous study, these compounds showed potent antiproliferative activity and efficiently inhibited topoisomerase IIα. To further extend the structure–activity relationships on pyrimido-pyrimidines, a novel series...

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Bibliographic Details
Main Authors: Andrea Spallarossa, Matteo Lusardi, Chiara Caneva, Aldo Profumo, Camillo Rosano, Marco Ponassi
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
pyrimido-pyrimidine derivatives
antiproliferative agents
structure activity relationships (SAR) study
docking simulation
Online Access:https://www.mdpi.com/1420-3049/26/3/557

Internet

https://www.mdpi.com/1420-3049/26/3/557

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