Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium

Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium

Small GTPase Rap1 plays a prominent role in endothelial cell (EC) homeostasis by promoting NO release. Endothelial deletion of the two highly homologous Rap1 isoforms, Rap1A and Rap1B, leads to endothelial dysfunction ex vivo and hypertension in vivo. Mechanistically, we showed that Rap1B promotes N...

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Bibliographic Details
Main Authors: Ramoji Kosuru, Bandana Singh, Sribalaji Lakshmikanthan, Yoshinori Nishijima, Jeannette Vasquez-Vivar, David X. Zhang, Magdalena Chrzanowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
endothelial (dys)function
vasodilation
nitric oxide signaling
small GTP protein
Rap1A
Rap1B
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.687598/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.687598/full

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