Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster

Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster

Among the nine dominantly inherited, age-dependent neurodegenerative diseases caused by abnormal expansion in the polyglutamine (polyQ) repeat of otherwise unrelated proteins is Spinocerebellar Ataxia Type 3 (SCA3). SCA3 is caused by polyQ expansion in the deubiquitinase (DUB), ataxin-3. Molecular s...

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Bibliographic Details
Main Authors: Gorica Ristic, Joanna R. Sutton, Kozeta Libohova, Sokol V. Todi
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Neurobiology of Disease
Subjects:
AAA ATPase
Ataxia
Ataxin-3
Deubiquitinase
Machado-Joseph Disease
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301219

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http://www.sciencedirect.com/science/article/pii/S0969996118301219

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