Inhibitory Effects of Simvastatin on Oxidized Low-Density Lipoprotein-Induced Endoplasmic Reticulum Stress and Apoptosis in Vascular Endothelial Cells

Inhibitory Effects of Simvastatin on Oxidized Low-Density Lipoprotein-Induced Endoplasmic Reticulum Stress and Apoptosis in Vascular Endothelial Cells

Background: Oxidized low-density lipoprotein (ox-LDL)-induced oxidative stress and endothelial apoptosis are essential for atherosclerosis. Our previous study has shown that ox-LDL-induced apoptosis is mediated by the protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic translation...

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Bibliographic Details
Main Authors: Guo-Qiang Zhang, Yong-Kang Tao, Yong-Ping Bai, Sheng-Tao Yan, Shui-Ping Zhao
Format: Article
Language:English
Published: Wolters Kluwer 2018-01-01
Series:Chinese Medical Journal
Subjects:
Apoptosis; Endoplasmic Reticulum Stress; Endothelial Cells; Oxidized Low-Density Lipoprotein; Simvastatin
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=8;spage=950;epage=955;aulast=Zhang

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http://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=8;spage=950;epage=955;aulast=Zhang

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