Dimeric bisbenzimidazoles DB(n) in combination with ionizing radiation decrease number and clonogenic activity of MCF-7 breast cancer stem cells

Dimeric bisbenzimidazoles DB(n) in combination with ionizing radiation decrease number and clonogenic activity of MCF-7 breast cancer stem cells

Purpose of the study was search for agents to eliminate the pool of cancer stem cells (CSCs) and increase their radiosensitivity among DNA minor groove binding ligands, synthetic dimeric bisbenzimidazoles of the DB(n) series, where n is the number of methylene groups in the linker connecting two bi...

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Bibliographic Details
Main Authors: Irina A. Zamulaeva, Kristina A. Churyukina, Olga N. Matchuk, Alexander A. Ivanov, Vyacheslav O. Saburov, Alexei L. Zhuze
Format: Article
Language:English
Published: AIMS Press 2020-12-01
Series:AIMS Biophysics
Subjects:
cancer stem cells
dimeric bisbenzimidazoles
ionizing radiation
combined effect
flow cytometry
Online Access:http://www.aimspress.com/article/doi/10.3934/biophy.2020024?viewType=HTML

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http://www.aimspress.com/article/doi/10.3934/biophy.2020024?viewType=HTML

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