A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells

A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells

Abstract Lung carcinoids are variably aggressive and mechanistically understudied neuroendocrine neoplasms (NENs). Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. miR-375 and YAP are respectively high and low expressed in...

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Bibliographic Details
Main Authors: Xiaojing Yang, Jina Nanayakkara, Duncan Claypool, Sadegh Saghafinia, Justin J. M. Wong, Minqi Xu, Xiantao Wang, Christopher J. B. Nicol, Iacovos P. Michael, Markus Hafner, Xiaolong Yang, Neil Renwick
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89855-4

Internet

https://doi.org/10.1038/s41598-021-89855-4

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