SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging

SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging

Maintaining the health of the endothelium is of critical importance to prevention against cell aging. The current study was performed to clarify the role of sirtuin1 (SIRT1) in platelet phagocytosis in cell aging and identified its downstream molecular mechanism. Platelet phagocytosis by human endom...

Full description

Bibliographic Details
Main Authors:	Yong Lan, Min Dong, Yongjun Li, Yongpeng Diao, Zuoguang Chen, Yangfang Li
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Series:	Molecular Therapy: Nucleic Acids
Subjects:	SIRT1 Akt GIRDIN human endometrial microvascular endothelial cells platelet phagocytosis cell aging
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253121000238

Similar Items

The role of Dlg5 in the progression of human prostate cancer
by: Tomiyama, Lucia
Published: (2014)

Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway
by: Ke H, et al.
Published: (2020-09-01)

Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7
by: Jia Yu, et al.
Published: (2017-01-01)

Nicotinamide Supplementation during the In Vitro Maturation of Oocytes Improves the Developmental Competence of Preimplantation Embryos: Potential Link to SIRT1/AKT Signaling
by: Marwa El Sheikh, et al.
Published: (2020-06-01)

SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression
by: Fangce Wang, et al.
Published: (2021-08-01)

Anti-Invasion and Antiangiogenic Effects of Stellettin B through Inhibition of the Akt/Girdin Signaling Pathway and VEGF in Glioblastoma Cells
by: Shu-Yu Cheng, et al.
Published: (2019-02-01)

Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein
by: Mikel Garcia-Marcos, et al.
Published: (2020-09-01)

Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism
by: Li Yu, et al.
Published: (2017-08-01)

MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways
by: Xiao-Zhi Bai, et al.
Published: (2018-08-01)

Acacetin Protects Against High Glucose-Induced Endothelial Cells Injury by Preserving Mitochondrial Function via Activating Sirt1/Sirt3/AMPK Signals
by: Wei-Min Han, et al.
Published: (2020-12-01)

Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway
by: Mengling Li, et al.
Published: (2020-09-01)

Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1α pathway
by: Li X, et al.
Published: (2019-03-01)

Effect of Biomphalaria straminea plasma in the phagocytosis of Biomphalaria glabrata hemolymph cells
by: Elizabeth Malagueño, et al.
Published: (1998-01-01)

GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility
by: Sequoyah Reynoso, et al.
Published: (2021-08-01)

SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability
by: Miao Yu, et al.
Published: (2020-06-01)

Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage
by: Jiaxiang Shao, et al.
Published: (2016-03-01)

Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation
by: Johannes Westman, et al.
Published: (2020-01-01)

Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway
by: Yanping Wang, et al.
Published: (2020-12-01)

The Phagocytic Code Regulating Phagocytosis of Mammalian Cells
by: Tom O. J. Cockram, et al.
Published: (2021-06-01)

MicroRNA-29b-3p Promotes Human Retinal Microvascular Endothelial Cell Apoptosis via Blocking SIRT1 in Diabetic Retinopathy
by: Yong Zeng, et al.
Published: (2020-01-01)

SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
by: Elizabeth V. Minten, et al.
Published: (2021-03-01)

<i>Drosophila</i> Hook-Related Protein (Girdin) is Essential for Sensory Dendrite Maintenance
by: Ha, Andrew
Published: (2015)

Girdin Knockdown Increases Gemcitabine Chemosensitivity to Pancreatic Cancer by Modulating Autophagy
by: Sheng Wang, et al.
Published: (2021-03-01)

ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis
by: Ok-Seon Kwon, et al.
Published: (2020-04-01)

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
by: Hui Zhang, et al.
Published: (2016-02-01)

Mammalian Sirt1: insights on its biological functions
by: Islam Rezuanul, et al.
Published: (2011-05-01)

Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK
by: Wang J, et al.
Published: (2018-11-01)

SIRT1 Regulates the Inflammatory Response of Vascular Adventitial Fibroblasts through Autophagy and Related Signaling Pathway
by: Wei-Rong Wang, et al.
Published: (2017-02-01)

Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE−/− mice
by: Tieying Yin, et al.
Published: (2021-04-01)

Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus
by: Marco De Zuani, et al.
Published: (2018-11-01)

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6–HMGB1 deacetylation
by: Wenqian Wei, et al.
Published: (2021-04-01)

Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
by: Morita Yoshihiro, et al.
Published: (2012-02-01)

Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis
by: Sofie Vandendriessche, et al.
Published: (2021-02-01)

Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway
by: Un-Jung Yun, et al.
Published: (2020-03-01)

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit
by: Wang X, et al.
Published: (2018-09-01)

Physical Constraints and Forces Involved in Phagocytosis
by: Valentin Jaumouillé, et al.
Published: (2020-06-01)

Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia
by: Paweł K. Łysyganicz, et al.
Published: (2021-06-01)

Spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis: a case report
by: Manabu Yamazaki, et al.
Published: (2021-08-01)

Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro
by: Christiane Muth, et al.
Published: (2019-05-01)

SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma
by: Wenmei Lu, et al.
Published: (2021-01-01)