Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization.

Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization.

Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected macaques, whereas natural reservoir hosts exhibit limited disease and pathology. It is, however, unclear how natural hosts can sustain high viral loads, comparable to those observed in the pathogenic model, withou...

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Bibliographic Details
Main Authors: Sharon Lederer, David Favre, Kathie-Anne Walters, Sean Proll, Bittoo Kanwar, Zeljka Kasakow, Carole R Baskin, Robert Palermo, Joseph M McCune, Michael G Katze
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2633618?pdf=render

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http://europepmc.org/articles/PMC2633618?pdf=render

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