Overcoming Resistance to FLT3 Inhibitors in the Treatment of <i>FLT3</i>-Mutated AML

Acute myeloid leukaemia (AML) carrying internal tandem duplication (ITD) of Fms-Like Tyrosine kinase 3 (<i>FLT3</i>) gene is associated with high risk of relapse and poor clinical outcome upon treatment with conventional chemotherapy. FLT3 inhibitors have been approved for the treatment...

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Bibliographic Details
Main Authors: Stephen S.Y. Lam, Anskar Y.H. Leung
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
aml
Online Access:https://www.mdpi.com/1422-0067/21/4/1537