Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I.

Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I.

Short-chain quinones have been investigated as therapeutic molecules due to their ability to modulate cellular redox reactions, mitochondrial electron transfer and oxidative stress, which are pathologically altered in many mitochondrial and neuromuscular disorders. Recently, we and others described...

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Bibliographic Details
Main Authors: Michael Erb, Barbara Hoffmann-Enger, Holger Deppe, Michael Soeberdt, Roman H Haefeli, Christian Rummey, Achim Feurer, Nuri Gueven
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338594?pdf=render

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http://europepmc.org/articles/PMC3338594?pdf=render

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