Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas

Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas

Inflammatory breast cancer (IBC) is the most aggressive and lethal form of breast cancer, characterized by a high infiltration of tumor-associated macrophages and poor prognosis. To identify new biomarkers and to elucidate the molecular mechanisms underlying IBC pathogenesis, we investigated the exp...

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Bibliographic Details
Main Authors: Mennatullah El-Nadi, Hebatallah Hassan, Moshira Ezzat Saleh, Eyyad Nassar, Yahia Mahmoud Ismail, Mahmoud Amer, Burkhard Greve, Martin Götte, Mohamed El-Shinawi, Sherif Abdelaziz Ibrahim
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Matrix Biology Plus
Subjects:
Inflammatory breast cancer
Triple negative subtype
Heparanase
Cathepsin L
CD163+ M2-type tumor-associated macrophages
Invasion
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028520300119

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http://www.sciencedirect.com/science/article/pii/S2590028520300119

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