Platycodin D Inhibits Inflammatory Response in LPS-Stimulated Primary Rat Microglia Cells through Activating LXRα–ABCA1 Signaling Pathway

Platycodin D Inhibits Inflammatory Response in LPS-Stimulated Primary Rat Microglia Cells through Activating LXRα–ABCA1 Signaling Pathway

Platycodin D (PLD), an effective triterpenesaponin extracted from Platycodon grandiflorum, has been known to have anti-inflammatory effect. In the present study, we investigate the anti-inflammatory effects of PLD on LPS-induced inflammation in primary rat microglia cells. The results showed that PL...

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Bibliographic Details
Main Authors: Yunhe Fu, Zhuoyuan Xin, Bin Liu, Jiaxin Wang, Jingjing Wang, Xu Zhang, Yanan Wang, Fan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
platycodin D
LPS
TLR4
NF-κB
LXRα
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01929/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01929/full

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