Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow under conditions when the classical respiratory ch...

Full description

Bibliographic Details
Main Authors: Marten Szibor, Praveen K. Dhandapani, Eric Dufour, Kira M. Holmström, Yuan Zhuang, Isabelle Salwig, Ilka Wittig, Juliana Heidler, Zemfira Gizatullina, Timur Gainutdinov, German Mouse Clinic Consortium, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Jatin Nandania, Vidya Velagapudi, Astrid Wietelmann, Pierre Rustin, Frank N. Gellerich, Howard T. Jacobs, Thomas Braun
Format: Article
Language:English
Published: The Company of Biologists 2017-02-01
Series:Disease Models & Mechanisms
Subjects:
Mitochondria
Mitochondrial disease
Respiratory chain
Alternative oxidase
Online Access:http://dmm.biologists.org/content/10/2/163

Internet

http://dmm.biologists.org/content/10/2/163

Similar Items