Conditional astroglial Rictor overexpression induces malignant glioma in mice.

Conditional astroglial Rictor overexpression induces malignant glioma in mice.

Hyperactivation of the mTORC2 signaling pathway has been shown to contribute to the oncogenic properties of gliomas. Moreover, overexpression of the mTORC2 regulatory subunit Rictor has been associated with increased proliferation and invasive character of these tumor cells.To determine whether Rict...

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Bibliographic Details
Main Authors: Tariq Bashir, Cheri Cloninger, Nicholas Artinian, Lauren Anderson, Andrew Bernath, Brent Holmes, Angelica Benavides-Serrato, Nesrin Sabha, Robert N Nishimura, Abhijit Guha, Joseph Gera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3471885?pdf=render

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http://europepmc.org/articles/PMC3471885?pdf=render

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