Reduced Expression of Cytoskeletal and Extracellular Matrix Genes in Human Adult Retinal Pigment Epithelium Cells Exposed to Simulated Microgravity

Reduced Expression of Cytoskeletal and Extracellular Matrix Genes in Human Adult Retinal Pigment Epithelium Cells Exposed to Simulated Microgravity

Background/Aims: Microgravity (µg) has adverse effects on the eye of humans in space. The risk of visual impairment is therefore one of the leading health concerns for NASA. The impact of µg on human adult retinal epithelium (ARPE-19) cells is unknown. Methods: In this study we investigated the infl...

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Bibliographic Details
Main Authors: Thomas J. Corydon, Vivek Mann, Lasse Slumstrup, Sascha Kopp, Jayashree Sahana, Anne Louise Askou, Nils E. Magnusson, David Echegoyen, Toke Bek, Alamelu Sundaresan, Stefan Riwaldt, Johann Bauer, Manfred Infanger, Daniela Grimm
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Simulated microgravity
Retinal pigment epithelium cells
3D growth
Spheroids
Gene expression
Random Positioning Machine
Cytoskeleton
Vascular endothelial growth factor
Online Access:http://www.karger.com/Article/FullText/452520

Internet

http://www.karger.com/Article/FullText/452520

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