Engineering Pathways in Central Carbon Metabolism Help to Increase Glycan Production and Improve <i>N</i>-Type Glycosylation of Recombinant Proteins in <i>E. coli</i>

Engineering Pathways in Central Carbon Metabolism Help to Increase Glycan Production and Improve <i>N</i>-Type Glycosylation of Recombinant Proteins in <i>E. coli</i>

<i>Escherichia coli</i> strains have been modified in a variety of ways to enhance the production of different recombinant proteins, targeting membrane protein expression, proteins with disulphide bonds, and more recently, proteins which require <i>N</i>-linked glycosylation....

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Bibliographic Details
Main Authors: Benjamin Strutton, Stephen RP Jaffe, Caroline A Evans, Gregory JS Fowler, Paul D Dobson, Jagroop Pandhal, Phillip C Wright
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Bioengineering
Subjects:
<i>N</i>-glycosylation
<i>Escherichia coli</i>
glycosylation efficiency
cell engineering
recombinant protein production
Online Access:https://www.mdpi.com/2306-5354/6/1/27

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https://www.mdpi.com/2306-5354/6/1/27

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