Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice

Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice

Background: Sepsis is defined as end-organ dysfunction resulting from the host’s inflammatory response to infection. One of the most common sepsis-injured organs is the kidneys, resulting in acute kidney injury (AKI) that contributes to the high morbidity and mortality, especially patients in the in...

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Bibliographic Details
Main Authors: Qian Ren, Fan Guo, Sibei Tao, Rongshuang Huang, Liang Ma, Ping Fu
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Fisetin
Sepsis
Acute kidney injury
Lipopolysaccharide
Inflammation
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219353946

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http://www.sciencedirect.com/science/article/pii/S0753332219353946

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