Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE−/− mice by SC-435

Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE−/− mice by SC-435

Blocking intestinal bile acid absorption by inhibiting the apical sodium codependent bile acid transporter (ASBT) is a target for increasing hepatic bile acid synthesis and reducing plasma LDL cholesterol. SC-435 was identified as a potent inhibitor of ASBT (IC50 = 1.5 nM) in cells transfected with...

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Bibliographic Details
Main Authors: B. Ganesh Bhat, Stephen R. Rapp, Judith A. Beaudry, Nida Napawan, Dustie N. Butteiger, Kerri A. Hall, Christopher L. Null, Yi Luo, Bradley T. Keller
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein E
cholesterol
low density lipoprotein
apical sodium codependent bile acid transporter
farnesoid X receptor
enterohepatic
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337238

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http://www.sciencedirect.com/science/article/pii/S0022227520337238

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