The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington’s Disease and Its Comorbidities

The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington’s Disease and Its Comorbidities

Intracellular chloride levels in the brain are regulated primarily through the opposing effects of two cation-chloride co-transporters (CCCs), namely K<sup>+</sup>-Cl<sup>−</sup> co-transporter-2 (KCC2) and Na<sup>+</sup>-K<sup>+</sup>-Cl<sup>−&l...

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Bibliographic Details
Main Authors: Katie Andrews, Sunday Solomon Josiah, Jinwei Zhang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
GABAergic
Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup>−</sup> cotransporter 1 (NKCC1), K<sup>+</sup>-2Cl<sup>−</sup> cotransporter 2 (KCC2), Chloride (Cl<sup>−</sup>) homeostasis
Huntington’s disease
sleep disorders
Online Access:https://www.mdpi.com/1422-0067/21/23/9142

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https://www.mdpi.com/1422-0067/21/23/9142

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