Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma.

Asthma is a common allergic lung disease frequently affecting individuals with a prior history of eczema/atopic dermatitis (AD); however, the mechanism underlying the progression from AD to asthma (the so-called "atopic march") is unclear. Here we show that, like humans with AD, mice with...

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Bibliographic Details
Main Authors: Shadmehr Demehri, Mitsuru Morimoto, Michael J Holtzman, Raphael Kopan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19557146/?tool=EBI