Targeting ulcerative colitis by suppressing glucose uptake with ritonavir

Targeting ulcerative colitis by suppressing glucose uptake with ritonavir

Glucose is the preferred source of energy in activated inflammatory cells. Glucose uptake into the cell is ensured by a family of glucose uptake transporters (GLUTs), which have been identified as off-target molecules of the HIV protease inhibitor ritonavir. In this study, we examined the effect of...

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Bibliographic Details
Main Authors: Henrika Jodeleit, Omar Al-Amodi, Janina Caesar, Christina Villarroel Aguilera, Lesca Holdt, Roswitha Gropp, Florian Beigel, Matthias Siebeck
Format: Article
Language:English
Published: The Company of Biologists 2018-11-01
Series:Disease Models & Mechanisms
Subjects:
Ulcerative colitis
Metabolic switch
Glucose transporter
Ritonavir
NOD-scid IL-2Rγnull
Mouse model
Inflammation
Online Access:http://dmm.biologists.org/content/11/11/dmm036210

Internet

http://dmm.biologists.org/content/11/11/dmm036210

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